Interference-Free Electrochemical Detection of Nanomolar Dopamine Using Doped Polypyrrole and Silver Nanoparticles
نویسندگان
چکیده
Dopamine (3, 4-dihydroxyphenyl ethylamine, DA) is one of the most important neurotransmitters in the mammalian central nervous system. This paper presents a new approach to detect dopamine using an electrochemical sensor based on a composite made out of chitosan-stabilized silver nanoparticles and p-toluene sulfonic acid-doped ultrathin polypyrrole film, which exploits the synergy between the conducting polymer matrix and silver nanoparticles. These are characterized by TEM, XRD, UV-vis , FTIR, EDAX and the properties of the modified electrode is investigated by electrochemical impedance spectroscopy (EIS). The linear range is from 1x10M to 1.2x10M in 0.05M phosphate buffer (pH 7.0) with a correlation coefficient of 0.98 and an estimated detection limit of 0.58 nM is obtained. A mechanism for the oxidation of DA on the modified electrode is proposed. High sensitivity of the composite layer towards DA, without interference from ascorbic acid (AA), uric acid (UA),
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